Distinct phenotype of CD4+ T cells driving celiac disease identified in multiple autoimmune conditions.
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ABSTRACT:
SUBMITTER: Christophersen A
PROVIDER: S-EPMC6647859 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
Distinct phenotype of CD4<sup>+</sup> T cells driving celiac disease identified in multiple autoimmune conditions.
Christophersen Asbjørn A Lund Eivind G EG Snir Omri O Solà Elsa E Kanduri Chakravarthi C Dahal-Koirala Shiva S Zühlke Stephanie S Molberg Øyvind Ø Utz Paul J PJ Rohani-Pichavant Mina M Simard Julia F JF Dekker Cornelia L CL Lundin Knut E A KEA Sollid Ludvig M LM Davis Mark M MM
Nature medicine 20190325 5
Combining HLA-DQ-gluten tetramers with mass cytometry and RNA sequencing analysis, we find that gluten-specific CD4<sup>+</sup> T cells in the blood and intestines of patients with celiac disease display a surprisingly rare phenotype. Cells with this phenotype are also elevated in patients with systemic sclerosis and systemic lupus erythematosus, suggesting a way to characterize CD4<sup>+</sup> T cells specific for disease-driving antigens in multiple autoimmune conditions. ...[more]
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