Misunderstanding the preorganization concept can lead to confusions about the origin of enzyme catalysis.

ABSTRACT: Understanding the origin of the catalytic power of enzymes has both conceptual and practical importance. One of the most important finding from computational studies of enzyme catalysis is that a major part of the catalytic power is due to the preorganization of the enzyme active site. Unfortunately, misunderstanding of the nontrivial preorganization idea lead some to assume that it does not consider the effect of the protein residues. This major confusion reflects a misunderstanding of the statement that the interaction energy of the enzyme group and the transition state (TS) is similar to the corresponding interaction between the water molecules (in the reference system) and the TS, and that the catalysis is due to the reorganization free energy of the water molecules. Obviously, this fi

SUBMITTER: Jindal G 

PROVIDER: S-EPMC5760166 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature