Ontology highlight
ABSTRACT:
SUBMITTER: Chaffee KG
PROVIDER: S-EPMC5760284 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Chaffee Kari G KG Oberg Ann L AL McWilliams Robert R RR Majithia Neil N Allen Brian A BA Kidd John J Singh Nanda N Hartman Anne-Renee AR Wenstrup Richard J RJ Petersen Gloria M GM
Genetics in medicine : official journal of the American College of Medical Genetics 20170720 1
PurposePanel-based genetic testing has identified increasing numbers of patients with pancreatic ductal adenocarcinoma (PDAC) who carry germ-line mutations. However, small sample sizes or number of genes evaluated limit prevalence estimates of these mutations. We estimated prevalence of mutations in PDAC patients with positive family history.MethodsWe sequenced 25 cancer susceptibility genes in lymphocyte DNA from 302 PDAC patients in the Mayo Clinic Biospecimen Resource for Pancreatic Research ...[more]