Ontology highlight
ABSTRACT:
SUBMITTER: He Z
PROVIDER: S-EPMC5760353 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
He Zhuohao Z Guo Jing L JL McBride Jennifer D JD Narasimhan Sneha S Kim Hyesung H Changolkar Lakshmi L Zhang Bin B Gathagan Ronald J RJ Yue Cuiyong C Dengler Christopher C Stieber Anna A Nitla Magdalena M Coulter Douglas A DA Abel Ted T Brunden Kurt R KR Trojanowski John Q JQ Lee Virginia M-Y VM
Nature medicine 20171204 1
Alzheimer's disease (AD) is characterized by extracellular amyloid-β (Aβ) plaques and intracellular tau inclusions. However, the exact mechanistic link between these two AD lesions remains enigmatic. Through injection of human AD-brain-derived pathological tau (AD-tau) into Aβ plaque-bearing mouse models that do not overexpress tau, we recapitulated the formation of three major types of AD-relevant tau pathologies: tau aggregates in dystrophic neurites surrounding Aβ plaques (NP tau), AD-like ne ...[more]