TREM2 function impedes tau seeding in neuritic plaques.
Ontology highlight
ABSTRACT:
SUBMITTER: Leyns CEG
PROVIDER: S-EPMC6660358 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
TREM2 function impedes tau seeding in neuritic plaques.
Leyns Cheryl E G CEG Gratuze Maud M Narasimhan Sneha S Jain Nimansha N Koscal Lauren J LJ Jiang Hong H Manis Melissa M Colonna Marco M Lee Virginia M Y VMY Ulrich Jason D JD Holtzman David M DM
Nature neuroscience 20190624 8
Variants in the triggering receptor expressed on myeloid cells 2 (TREM2) have been associated with increased risk for sporadic, late-onset Alzheimer's disease. Here we show that germline knockout of Trem2 or the TREM2<sup>R47H</sup> variant reduces microgliosis around amyloid-β plaques and facilitates the seeding and spreading of neuritic plaque tau aggregates. These findings demonstrate a key role for TREM2 and microglia in limiting the development of peri-plaque tau pathologies. ...[more]
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