Ontology highlight
ABSTRACT:
SUBMITTER: Field MG
PROVIDER: S-EPMC5760704 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Field Matthew G MG Durante Michael A MA Anbunathan Hima H Cai Louis Z LZ Decatur Christina L CL Bowcock Anne M AM Kurtenbach Stefan S Harbour J William JW
Nature communications 20180109 1
Cancer is thought to arise through the accumulation of genomic aberrations evolving under Darwinian selection. However, it remains unclear when the aberrations associated with metastasis emerge during tumor evolution. Uveal melanoma (UM) is the most common primary eye cancer and frequently leads to metastatic death, which is strongly linked to BAP1 mutations. Accordingly, UM is ideally suited for studying the clonal evolution of metastatic competence. Here we analyze sequencing data from 151 pri ...[more]