Ontology highlight
ABSTRACT:
SUBMITTER: Baca SC
PROVIDER: S-EPMC3690918 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Cell 20130401 3
The analysis of exonic DNA from prostate cancers has identified recurrently mutated genes, but the spectrum of genome-wide alterations has not been profiled extensively in this disease. We sequenced the genomes of 57 prostate tumors and matched normal tissues to characterize somatic alterations and to study how they accumulate during oncogenesis and progression. By modeling the genesis of genomic rearrangements, we identified abundant DNA translocations and deletions that arise in a highly inter ...[more]