Ontology highlight
ABSTRACT:
SUBMITTER: Qu Y
PROVIDER: S-EPMC5761965 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Qu Yongming Y Luo Junxiang J Garhyan Parag P Antalis Caryl J CJ Chang Annette M AM Jacober Scott J SJ
Journal of diabetes science and technology 20170503 1
<h4>Background</h4>For new insulin analogs with properties that vary from human insulin, defining activity in units of human insulin based on glycemic lowering efficacy may be challenging. Here we present a new method that can be used to quantify a unit dose of an experimental insulin when the traditional euglycemic clamp method is not adequate.<h4>Methods</h4>Joint modeling of insulin dose and the glycemic outcome variable hemoglobin A1c (HbA1c), where both were response variables, was used to ...[more]