Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC5762335 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Zhang Yixin Y Cui Xiaoteng X Ning Li L Wei Dianjun D
Oncotarget 20171130 67
This meta-analysis of 23 eligible articles comprehensively and quantitatively evaluated the effects of tumor necrosis factor-α (<i>TNF-α</i>) rs1800629 and rs361525 polymorphisms on sepsis risk. We found that <i>TNF-α</i> rs1800629 was associated with increased sepsis risk in the overall population in four genetic models, including A vs. G (<i>P</i><0.001, odds ratio (OR)=1.32), GA vs. GG (<i>P</i><0.001, OR=1.46), GA+AA vs. GG (<i>P</i><0.001, OR=1.46), and carrier A vs. carrier G (<i>P</i><0.0 ...[more]