Dataset Information

No association between three polymorphisms (rs1800629, rs361525 and rs1799724) in the tumor necrosis factor-? gene and susceptibility to prostate cancer: a comprehensive meta-analysis.

ABSTRACT: Inflammation is one of the factors associated with prostate cancer. The cytokine tumor necrosis factor-alpha (TNF-?) plays an important role in inflammation. Several studies have focused on the association between TNF-? polymorphisms and prostate cancer development. Our meta-analysis aimed to estimate the association between TNF-? rs1800629 (-?308?G/A), rs361525 (-?238?G/A) and rs1799724 polymorphisms and prostate cancer risk. Eligible studies were identified from electronic databases (PubMed, Embase, Wanfang and CNKI) using keywords: TNF-?, polymorphism, prostate cancer, until Nov 15, 2019. Odds ratios (ORs) with 95% confidence intervals (CIs) were applied to determine the association from a quantitative point-of-view. Publication bias and sensitivity analysis were also applied to evaluate the power of current study. All statistical analyses were done with Stata 11.0 software. Twenty-two different articles were included (22 studies about rs1800629; 8 studies for rs361525 and 5 studies related to rs1799724). Overall, no significant association was found between rs1800629 and rs1799724 polymorphisms and the risk of prostate cancer in the whole (such as: OR?=?1.03, 95% CI?=?0.92-1.16, P =?0.580 in the allele for rs1800629; OR?=?0.95, 95% CI?=?0.84-1.07, P =?0.381 in the allele for rs1799724). The rs361525 polymorphism also had no association with prostate cancer in the cases (OR?=?0.93, 95% CI?=?0.66-1.32, P =?0.684 in the allele) and ethnicity subgroup. The stratified subgroup of genotype method, however, revealed that the rs361525 variant significantly decreased the risk of prostate cancer in the Others (OR?=?0.65, 95% CI?=?0.47-0.89, P?=?0.008, A-allele vs G-allele) and PCR-RFLP (OR?=?2.68, 95% CI?=?1.00-7.20, P?=?0.050, AG vs GG or AA+AG vs GG) methods. In summary, the findings of the current meta-analysis indicate that the TNF-? rs1800629, rs361525 and rs1799724 polymorphisms are not correlated with prostate cancer development, although there were some pooled positive results. Further well-designed studies are necessary to form more precise conclusions.

SUBMITTER: Yin L

PROVIDER: S-EPMC7137332 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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No association between three polymorphisms (rs1800629, rs361525 and rs1799724) in the tumor necrosis factor-α gene and susceptibility to prostate cancer: a comprehensive meta-analysis.

Yin Lei L Yue Chuang C Jing Hongwei H Yu Hongyuan H Zuo Li L Liu Tao T

Hereditas 20200407 1

<h4>Background</h4>Inflammation is one of the factors associated with prostate cancer. The cytokine tumor necrosis factor-alpha (TNF-α) plays an important role in inflammation. Several studies have focused on the association between TNF-α polymorphisms and prostate cancer development. Our meta-analysis aimed to estimate the association between TNF-α rs1800629 (- 308 G/A), rs361525 (- 238 G/A) and rs1799724 polymorphisms and prostate cancer risk.<h4>Methods</h4>Eligible studies were identified fr ...[more]

PMID: 32264962

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Project description:The multifactorial pathogenesis of severe malaria is partly attributed to host genes, such as those encoding cytokines involved in complex inflammatory reactions, namely tumor necrosis factor-alpha (TNF-α). However, the relationship between TNF-α -308G >A gene polymorphism (rs1800629) and the severity of Plasmodium falciparum (P. falciparum) malaria remains unclear, which prompts a meta-analysis to obtain more precise estimates. The present meta-analysis aimed to better understand this correlation and provide insight into its association in populations with different ethnicities. Literature search outcomes included eight eligible articles in which TNF-α -308G >A polymorphism was determined in uncomplicated malaria (UM) and severe malaria (SM) of P. falciparum as represented in the case and control groups. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated in standard homozygous, recessive, dominant, and codominant genetic models. Subgroup analysis was based on ethnicity, i.e., Africans and Asians. The analyses included overall and the modified outcomes; the latter was obtained without the studies that deviated from the Hardy-Weinberg Equilibrium. The significant data also underwent sensitivity treatment but not publication bias tests because the number of studies was less than ten. Interaction tests were applied to differential outcomes between the subgroups. Overall and HWE-compliant analyses showed no significant association between the TNF-α -308G >A polymorphism and susceptibility to P. falciparum SM (ORs = 1.10-1.52, 95%CIs = 0.68-2.79; Pa = 0.24-0.68). Stratification by ethnicity revealed that two significant associations were found only in the Asians favoring SM for dominant (OR = 1.95, 95% CI = 1.06-3.61, Pa = 0.03) and codominant (OR = 1.83, 95% CI = 1.15-2.92, Pa = 0.01) under the random-effects model, but not among the African populations. The two significant Asian associations were improved with a test of interaction with P-value of0.02-0.03. The significant core outcomes were robust. Results of the meta-analysis suggest that TNF-α -308G >A polymorphism might affect the risk of P. falciparum SM, particularly in individuals of Asian descent. This supports ethnicity as one of the dependent factors of the TNF-α -308G >A association with the clinical severity of malaria. Further large and well-designed genetic studies are needed to confirm this conclusion.

Dataset Information

No association between three polymorphisms (rs1800629, rs361525 and rs1799724) in the tumor necrosis factor-? gene and susceptibility to prostate cancer: a comprehensive meta-analysis.

Publications

No association between three polymorphisms (rs1800629, rs361525 and rs1799724) in the tumor necrosis factor-α gene and susceptibility to prostate cancer: a comprehensive meta-analysis.

Similar Datasets

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