Dataset Information

No association between three polymorphisms (rs1800629, rs361525 and rs1799724) in the tumor necrosis factor-? gene and susceptibility to prostate cancer: a comprehensive meta-analysis.

ABSTRACT: Inflammation is one of the factors associated with prostate cancer. The cytokine tumor necrosis factor-alpha (TNF-?) plays an important role in inflammation. Several studies have focused on the association between TNF-? polymorphisms and prostate cancer development. Our meta-analysis aimed to estimate the association between TNF-? rs1800629 (-?308?G/A), rs361525 (-?238?G/A) and rs1799724 polymorphisms and prostate cancer risk. Eligible studies were identified from electronic databases (PubMed, Embase, Wanfang and CNKI) using keywords: TNF-?, polymorphism, prostate cancer, until Nov 15, 2019. Odds ratios (ORs) with 95% confidence intervals (CIs) were applied to determine the association from a quantitative point-of-view. Publication bias and sensitivity analysis were also applied to evaluate the power of current study. All statistical analyses were done with Stata 11.0 software. Twenty-two different articles were included (22 studies about rs1800629; 8 studies for rs361525 and 5 studies related to rs1799724). Overall, no significant association was found between rs1800629 and rs1799724 polymorphisms and the risk of prostate cancer in the whole (such as: OR?=?1.03, 95% CI?=?0.92-1.16, P =?0.580 in the allele for rs1800629; OR?=?0.95, 95% CI?=?0.84-1.07, P =?0.381 in the allele for rs1799724). The rs361525 polymorphism also had no association with prostate cancer in the cases (OR?=?0.93, 95% CI?=?0.66-1.32, P =?0.684 in the allele) and ethnicity subgroup. The stratified subgroup of genotype method, however, revealed that the rs361525 variant significantly decreased the risk of prostate cancer in the Others (OR?=?0.65, 95% CI?=?0.47-0.89, P?=?0.008, A-allele vs G-allele) and PCR-RFLP (OR?=?2.68, 95% CI?=?1.00-7.20, P?=?0.050, AG vs GG or AA+AG vs GG) methods. In summary, the findings of the current meta-analysis indicate that the TNF-? rs1800629, rs361525 and rs1799724 polymorphisms are not correlated with prostate cancer development, although there were some pooled positive results. Further well-designed studies are necessary to form more precise conclusions.

SUBMITTER: Yin L

PROVIDER: S-EPMC7137332 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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No association between three polymorphisms (rs1800629, rs361525 and rs1799724) in the tumor necrosis factor-α gene and susceptibility to prostate cancer: a comprehensive meta-analysis.

Yin Lei L Yue Chuang C Jing Hongwei H Yu Hongyuan H Zuo Li L Liu Tao T

Hereditas 20200407 1

<h4>Background</h4>Inflammation is one of the factors associated with prostate cancer. The cytokine tumor necrosis factor-alpha (TNF-α) plays an important role in inflammation. Several studies have focused on the association between TNF-α polymorphisms and prostate cancer development. Our meta-analysis aimed to estimate the association between TNF-α rs1800629 (- 308 G/A), rs361525 (- 238 G/A) and rs1799724 polymorphisms and prostate cancer risk.<h4>Methods</h4>Eligible studies were identified fr ...[more]

PMID: 32264962

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Project description:OBJECTIVE:Several published studies have investigated the association between the -308G/A (rs1800629) polymorphism in the tumor necrosis factor-? (TNF-?) gene and the risk of dilated cardiomyopathy (DCM). However, the TNF-? gene polymorphism has a controversial role in the pathogenesis of DCM among different populations. In the present study, a meta-analysis was performed to resolve this inconsistency. METHODS:Potentially eligible papers reporting an association between the TNF-? rs1800629 polymorphism and DCM susceptibility were searched in 4 databases including PubMed, EMBASE, Chinese Biomedical Database (CBM), and the Cochrane Library up to April 1, 2018. The odds ratio (OR) with its 95% confidence interval (CI) was used to estimate the strength of the associations. Subgroup analysis based on the ethnicity, studies with or without ischemic and valvular DCM was conducted. Publication bias detection was conducted using Begg test. RESULTS:Nine papers detailing case-control studies were included, reporting a total of 1339 DCM cases and 1677 healthy controls. The meta-analysis results indicated that TNF-? rs1800629 was associated with increased DCM susceptibility in the populations studied under the heterozygous model (AG vs GG: OR?=?1.91, 95% CI?=?1.05-3.50, P?=?.035) and dominant model (AG?+?AA vs GG: OR?=?1.87, 95% CI?=?1.01-3.45, P?=?.046). In the subgroup analysis for ethnicity, rs1800629 polymorphism was significantly associated with the susceptibility of DCM for Asians under the 5 models (A vs G: OR?=?2.87, 95% CI?=?1.56-5.30, P?=?.001; AA vs GG: OR?=?3.95, 95% CI?=?1.13-13.82, P?=?0.031; AG vs GG: OR?=?3.8, 95% CI?=?1.57-9.19, P?=?.003; AA vs GG?+?AG: OR?=?2.51, 95% CI?=?1.41-4.49, P?=?.002; AG?+?AA vs GG: OR?=?3.77, 95% CI?=?1.54-9.20, P?=?.004). CONCLUSION:There may be a moderate association between TNF-? rs1800629 polymorphism and DCM susceptibility in the whole populations studied; however, TNF-? rs1800629 polymorphism was significantly associated with the susceptibility of DCM for Asians, which indicates that such associations may be different between ethnicities.

Dataset Information

No association between three polymorphisms (rs1800629, rs361525 and rs1799724) in the tumor necrosis factor-? gene and susceptibility to prostate cancer: a comprehensive meta-analysis.

Publications

No association between three polymorphisms (rs1800629, rs361525 and rs1799724) in the tumor necrosis factor-α gene and susceptibility to prostate cancer: a comprehensive meta-analysis.

Similar Datasets

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