Ontology highlight
ABSTRACT:
SUBMITTER: Kugaevskaya EV
PROVIDER: S-EPMC5762728 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Kugaevskaya Elena V EV Veselovsky Alexander V AV Indeykina Maria I MI Solovyeva Nina I NI Zharkova Maria S MS Popov Igor A IA Nikolaev Eugene N EN Mantsyzov Alexey B AB Makarov Alexander A AA Kozin Sergey A SA
Scientific reports 20180110 1
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder. Amyloid-β (Aβ) aggregation is likely to be the major cause of AD. In contrast to humans and other mammals, that share the same Aβ sequence, rats and mice are invulnerable to AD-like neurodegenerative pathologies, and Aβ of these rodents (ratAβ) has three amino acid substitutions in the metal-binding domain 1-16 (MBD). Angiotensin-converting enzyme (ACE) cleaves Aβ-derived peptide substrates, however, there are contradiction ...[more]