Ontology highlight
ABSTRACT:
SUBMITTER: Liang Q
PROVIDER: S-EPMC5762844 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Cell death and differentiation 20171006 2
Astrocyte has crucial roles in the central nervous system and accumulating evidence has shown its core function for brain complexity, plasticity and cognition. However, the essential key factors in the precise regulation of astrocytic differentiation remain largely uncharacterized. Here, we identified that RNF20, an E3 ligase of H2BK120 in the mammalian system, regulates astrocyte production from neural precursor cells. RNF20 deficiency by shRNA knockdown or deletion in conditional knockout mice ...[more]