Ontology highlight
ABSTRACT:
SUBMITTER: Wilmanski T
PROVIDER: S-EPMC5763507 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Wilmanski Tomasz T Zhou Xuanzhu X Zheng Wei W Shinde Aparna A Donkin Shawn S SS Wendt Michael M Burgess John R JR Teegarden Dorothy D
Cancer letters 20171009
Maintaining reductive-oxidative (redox) balance is an essential feature in breast cancer cell survival, with cellular metabolism playing an integral role in maintaining redox balance through its supply of reduced NADPH. In the present studies, the effect of 1,25-dihydroxyvitamin D (1,25(OH)<sub>2</sub>D) on redox balance was investigated in early stages of breast cancer. Treatment with 1,25(OH)<sub>2</sub>D promoted oxidative stress in MCF10A-ras and MCF10A-ErbB2 breast epithelial cells, as meas ...[more]