Ontology highlight
ABSTRACT:
SUBMITTER: Lin Q
PROVIDER: S-EPMC7201266 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Lin Qingxiang Q He Yuan Y Wang Xue X Zhang Yong Y Hu Meichun M Guo Weikai W He Yundong Y Zhang Tao T Lai Li L Sun Zhenliang Z Yi Zhengfang Z Liu Mingyao M Chen Yihua Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20200312 9
Rapid metabolism differentiates cancer cells from normal cells and relies on anaplerotic pathways. However, the mechanisms of anaplerosis-associated enzymes are rarely understood. The lack of potent and selective antimetabolism drugs restrains further clinical investigations. A small molecule ZY-444 ((<i>N</i> <sup>4</sup>-((5-(4-(benzyloxy)phenyl)-2-thiophenyl)methyl)-<i>N</i> <sup>2</sup>-isobutyl-2,4-pyrimidinediamine) is discovered to inhibit cancer cell proliferation specifically, having po ...[more]