Ontology highlight
ABSTRACT:
SUBMITTER: Brumbaugh J
PROVIDER: S-EPMC5766360 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Brumbaugh Justin J Di Stefano Bruno B Wang Xiuye X Borkent Marti M Forouzmand Elmira E Clowers Katie J KJ Ji Fei F Schwarz Benjamin A BA Kalocsay Marian M Elledge Stephen J SJ Chen Yue Y Sadreyev Ruslan I RI Gygi Steven P SP Hu Guang G Shi Yongsheng Y Hochedlinger Konrad K
Cell 20171214 1-2
Cell fate transitions involve rapid gene expression changes and global chromatin remodeling, yet the underlying regulatory pathways remain incompletely understood. Here, we identified the RNA-processing factor Nudt21 as a novel regulator of cell fate change using transcription-factor-induced reprogramming as a screening assay. Suppression of Nudt21 enhanced the generation of induced pluripotent stem cells, facilitated transdifferentiation into trophoblast stem cells, and impaired differentiation ...[more]