Ontology highlight
ABSTRACT:
SUBMITTER: Moghbeli M
PROVIDER: S-EPMC5766466 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Moghbeli Meysam M Naghibzadeh Bahram B Ghahraman Martha M Fatemi Sedigheh S Taghavi Morteza M Vakili Rahim R Abbaszadegan Mohammad Reza MR
Indian journal of clinical biochemistry : IJCB 20170413 1
Mutations in hepatocyte nuclear factor-1 alpha (HNF1A) as a homeodomain transcription factor which regulates variety of genes, are the most common cause of maturity-onset diabetes of the young (MODY). Detection of HNF1A mutations not only classifies the subtype, but also predicts the likely clinical course and may alters the method of treatment from insulin to the oral sulphonylureas, which is shown to improve glycemic control. The coding and promoter regions of <i>HNF1A</i> gene were screened f ...[more]