Ontology highlight
ABSTRACT:
SUBMITTER: Ruiz A
PROVIDER: S-EPMC5766524 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Ruiz Alexis A Dror Erez E Handschin Christoph C Furrer Regula R Perez-Schindler Joaquin J Bachmann Christoph C Treves Susan S Zorzato Francesco F
Scientific reports 20180112 1
SRP-35 is a short-chain dehydrogenase/reductase belonging to the DHRS7C dehydrogenase/ reductase family 7. Here we show that its over-expression in mouse skeletal muscles induces enhanced muscle performance in vivo, which is not related to alterations in excitation-contraction coupling but rather linked to enhanced glucose metabolism. Over-expression of SRP-35 causes increased phosphorylation of Akt<sub>S473</sub>, triggering plasmalemmal targeting of GLUT4 and higher glucose uptake into muscles ...[more]