Ontology highlight
ABSTRACT:
SUBMITTER: Imamovic L
PROVIDER: S-EPMC5766827 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Imamovic Lejla L Ellabaan Mostafa Mostafa Hashim MMH Dantas Machado Ana Manuel AM Citterio Linda L Wulff Tune T Molin Soren S Krogh Johansen Helle H Sommer Morten Otto Alexander MOA
Cell 20180104 1-2
Chronic Pseudomonas aeruginosa infections evade antibiotic therapy and are associated with mortality in cystic fibrosis (CF) patients. We find that in vitro resistance evolution of P. aeruginosa toward clinically relevant antibiotics leads to phenotypic convergence toward distinct states. These states are associated with collateral sensitivity toward several antibiotic classes and encoded by mutations in antibiotic resistance genes, including transcriptional regulator nfxB. Longitudinal analysis ...[more]