Dataset Information

Antibody and B Cell Subset Perturbations in Human Immunodeficiency Virus-Uninfected Patients With Cryptococcosis.

ABSTRACT: The importance of antibody immunity in protection against Cryptococcus neoformans remains unresolved. We measured serum C neoformans-specific and total antibody levels and peripheral blood B cell subsets of 12 previously healthy patients with cryptococcosis (cases) and 21 controls. Before and after adjustment for age, sex, and race, cryptococcal capsular polysaccharide immunoglobulin G was higher in cases than controls, whereas total B and memory B cell levels were lower. These associations parallel previous findings in patients with human immunodeficiency virus-associated cryptococcosis and suggest that B cell subset perturbations may also associate with disease in previously normal individuals with cryptococcosis.

SUBMITTER: Rohatgi S

PROVIDER: S-EPMC5767948 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Antibody and B Cell Subset Perturbations in Human Immunodeficiency Virus-Uninfected Patients With Cryptococcosis.

Rohatgi Soma S Nakouzi Antonio A Carreño Leandro J LJ Slosar-Cheah Magdalena M Kuniholm Mark H MH Wang Tao T Pappas Peter G PG Pirofski Liise-Anne LA

Open forum infectious diseases 20171118 1

The importance of antibody immunity in protection against <i>Cryptococcus neoformans</i> remains unresolved. We measured serum <i>C neoformans</i>-specific and total antibody levels and peripheral blood B cell subsets of 12 previously healthy patients with cryptococcosis (cases) and 21 controls. Before and after adjustment for age, sex, and race, cryptococcal capsular polysaccharide immunoglobulin G was higher in cases than controls, whereas total B and memory B cell levels were lower. These ass ...[more]

PMID: 29354657

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Dataset Information

Antibody and B Cell Subset Perturbations in Human Immunodeficiency Virus-Uninfected Patients With Cryptococcosis.

Publications

Antibody and B Cell Subset Perturbations in Human Immunodeficiency Virus-Uninfected Patients With Cryptococcosis.

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