Ontology highlight
ABSTRACT:
SUBMITTER: Aschenbrenner J
PROVIDER: S-EPMC5768020 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20171207 2
Methods for the detection of RNA modifications are of fundamental importance for advancing epitranscriptomics. N<sup>6</sup> -methyladenosine (m<sup>6</sup> A) is the most abundant RNA modification in mammalian mRNA and is involved in the regulation of gene expression. Current detection techniques are laborious and rely on antibody-based enrichment of m<sup>6</sup> A-containing RNA prior to sequencing, since m<sup>6</sup> A modifications are generally "erased" during reverse transcription (RT). ...[more]