Unknown

Dataset Information

0

Prospective, Multicenter, Randomized, Crossover Clinical Trial Comparing the Safety and Effectiveness of Cooled Radiofrequency Ablation With Corticosteroid Injection in the Management of Knee Pain From Osteoarthritis.


ABSTRACT: BACKGROUND AND OBJECTIVES:Osteoarthritis (OA) of the knee affects the aging population and has an associated influence on the health care system. Rigorous studies evaluating radiofrequency ablation for OA-related knee pain are lacking. This study compared long-term clinical safety and effectiveness of cooled radiofrequency ablation (CRFA) with intra-articular steroid (IAS) injection in managing OA-related knee pain. METHODS:This is a prospective, multicenter, randomized trial with 151 subjects with chronic (?6 months) knee pain that was unresponsive to conservative modalities. Knee pain (Numeric Rating Scale [NRS]), Oxford Knee Score, overall treatment effect (Global Perceived Effect), analgesic drug use, and adverse events were compared between CRFA and IAS cohorts at 1, 3, and 6 months after intervention. RESULTS:There were no differences in demographics between study groups. At 6 months, the CRFA group had more favorable outcomes in NRS: pain reduction 50% or greater: 74.1% versus 16.2%, P < 0.0001 (25.9% and 83.8% of these study cohorts, respectively, were nonresponders). Mean NRS score reduction was 4.9 ± 2.4 versus 1.3 ± 2.2, P < 0.0001; mean Oxford Knee Score was 35.7 ± 8.8 vs 22.4 ± 8.5, P < 0.0001; mean improved Global Perceived Effect was 91.4% vs 23.9%, P < 0.0001; and mean change in nonopioid medication use was CRFA > IAS (P = 0.02). There were no procedure-related serious adverse events. CONCLUSIONS:This study demonstrates that CRFA is an effective long-term therapeutic option for managing pain and improving physical function and quality of life for patients with painful knee OA when compared with IAS injection. CLINICAL TRIAL REGISTRATION:ClinicalTrials.gov (NCT02343003).

SUBMITTER: Davis T 

PROVIDER: S-EPMC5768219 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Prospective, Multicenter, Randomized, Crossover Clinical Trial Comparing the Safety and Effectiveness of Cooled Radiofrequency Ablation With Corticosteroid Injection in the Management of Knee Pain From Osteoarthritis.

Davis Tim T   Loudermilk Eric E   DePalma Michael M   Hunter Corey C   Lindley David D   Patel Nilesh N   Choi Daniel D   Soloman Marc M   Gupta Anita A   Desai Mehul M   Buvanendran Asokumar A   Kapural Leonardo L  

Regional anesthesia and pain medicine 20180101 1


<h4>Background and objectives</h4>Osteoarthritis (OA) of the knee affects the aging population and has an associated influence on the health care system. Rigorous studies evaluating radiofrequency ablation for OA-related knee pain are lacking. This study compared long-term clinical safety and effectiveness of cooled radiofrequency ablation (CRFA) with intra-articular steroid (IAS) injection in managing OA-related knee pain.<h4>Methods</h4>This is a prospective, multicenter, randomized trial with  ...[more]

Similar Datasets

| S-EPMC7285532 | biostudies-literature
| S-EPMC7876515 | biostudies-literature
| S-EPMC6593544 | biostudies-literature
| S-EPMC9541208 | biostudies-literature
| S-EPMC10958262 | biostudies-literature
| S-EPMC9895122 | biostudies-literature
| S-EPMC5267419 | biostudies-literature
| S-EPMC9128114 | biostudies-literature
| S-EPMC8884338 | biostudies-literature
| S-EPMC8306337 | biostudies-literature