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The Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) R620W Functional Polymorphism in Psoriasis.

ABSTRACT: Background:Psoriasis is a complex autoimmune disease caused by the interaction of genetic and environmental factors. PTPN22 gene polymorphism has been reported to affect psoriasis susceptibility; however, no data are available for Middle Eastern populations. Objective:The aim of this study was to investigate the association of PTPN22 (1858C/T) R620W polymorphism with psoriasis in a Saudi cohort. Methods:Saudi subjects (n?=?306) including patients with psoriasis (n?=?106) and matched controls (n?=?200) were studied for PTPN22 variants using tetra-primer amplification refractory mutation system-polymerase chain reaction method. The frequencies of alleles and genotypes of PTPN22 (1858C/T) polymorphism were compared between patients and controls. Results:The frequency of CT genotype of PTPN22 (1858C/T) polymorphism was significantly higher, whereas that of CC genotype was lower in patients with psoriasis than in controls (P?

SUBMITTER: Bin Huraib G 

PROVIDER: S-EPMC5768248 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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The Protein Tyrosine Phosphatase Nonreceptor 22 (<i>PTPN22</i>) R620W Functional Polymorphism in Psoriasis.

Bin Huraib Ghaleb G   Al Harthi Fahad F   Arfin Misbahul M   Rizvi Sadaf S   Al-Asmari Abdulrahaman A  

Clinical medicine insights. Arthritis and musculoskeletal disorders 20180111

<h4>Background</h4>Psoriasis is a complex autoimmune disease caused by the interaction of genetic and environmental factors. <i>PTPN22</i> gene polymorphism has been reported to affect psoriasis susceptibility; however, no data are available for Middle Eastern populations.<h4>Objective</h4>The aim of this study was to investigate the association of PTPN22 (1858C/T) R620W polymorphism with psoriasis in a Saudi cohort.<h4>Methods</h4>Saudi subjects (n = 306) including patients with psoriasis (n =   ...[more]

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