Ontology highlight
ABSTRACT:
SUBMITTER: Nahar R
PROVIDER: S-EPMC5768770 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Nature communications 20180115 1
EGFR-mutant lung adenocarcinomas (LUAD) display diverse clinical trajectories and are characterized by rapid but short-lived responses to EGFR tyrosine kinase inhibitors (TKIs). Through sequencing of 79 spatially distinct regions from 16 early stage tumors, we show that despite low mutation burdens, EGFR-mutant Asian LUADs unexpectedly exhibit a complex genomic landscape with frequent and early whole-genome doubling, aneuploidy, and high clonal diversity. Multiple truncal alterations, including ...[more]