Ontology highlight
ABSTRACT:
SUBMITTER: Franks TM
PROVIDER: S-EPMC5769767 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Franks Tobias M TM McCloskey Asako A Shokirev Maxim Nikolaievich MN Benner Chris C Rathore Annie A Hetzer Martin W MW
Genes & development 20171101 22
Recent studies have shown that a subset of nucleoporins (Nups) can detach from the nuclear pore complex and move into the nuclear interior to regulate transcription. One such dynamic Nup, called Nup98, has been implicated in gene activation in healthy cells and has been shown to drive leukemogenesis when mutated in patients with acute myeloid leukemia (AML). Here we show that in hematopoietic cells, Nup98 binds predominantly to transcription start sites to recruit the Wdr82-Set1A/COMPASS (comple ...[more]