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JmjC domain proteins modulate circadian behaviors and sleep in Drosophila.

ABSTRACT: Jumonji (JmjC) domain proteins are known regulators of gene expression and chromatin organization by way of histone demethylation. Chromatin modification and remodeling provides a means to modulate the activity of large numbers of genes, but the importance of this class of predicted histone-modifying enzymes for different aspects of post-developmental processes remains poorly understood. Here we test the function of all 11 non-lethal members in the regulation of circadian rhythms and sleep. We find loss of every Drosophila JmjC gene affects different aspects of circadian behavior and sleep in a specific manner. Together these findings suggest that the majority of JmjC proteins function as regulators of behavior, rather than controlling essential developmental programs.

SUBMITTER: Shalaby NA

PROVIDER: S-EPMC5770425 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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JmjC domain proteins modulate circadian behaviors and sleep in Drosophila.

Shalaby Nevine A NA Pinzon Jorge H JH Narayanan Anjana S AS Jin Eugene Jennifer EJ Ritz Morgan P MP Dove Rachel J RJ Wolfenberg Heike H Rodan Aylin R AR Buszczak Michael M Rothenfluh Adrian A

Scientific reports 20180116 1

Jumonji (JmjC) domain proteins are known regulators of gene expression and chromatin organization by way of histone demethylation. Chromatin modification and remodeling provides a means to modulate the activity of large numbers of genes, but the importance of this class of predicted histone-modifying enzymes for different aspects of post-developmental processes remains poorly understood. Here we test the function of all 11 non-lethal members in the regulation of circadian rhythms and sleep. We f ...[more]

PMID: 29339751

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