Ontology highlight
ABSTRACT:
SUBMITTER: Stolle S
PROVIDER: S-EPMC5770778 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Stolle Sarah S Ciapaite Jolita J Reijne Aaffien C AC Talarovicova Alzbeta A Wolters Justina C JC Aguirre-Gamboa Raúl R van der Vlies Pieter P de Lange Kim K Neerincx Pieter B PB van der Vries Gerben G Deelen Patrick P Swertz Morris A MA Li Yang Y Bischoff Rainer R Permentier Hjalmar P HP Horvatovitch Peter L PL Groen Albert K AK van Dijk Gertjan G Reijngoud Dirk-Jan DJ Bakker Barbara M BM
Aging cell 20171109 1
Loss of mitochondrial respiratory flux is a hallmark of skeletal muscle aging, contributing to a progressive decline of muscle strength. Endurance exercise alleviates the decrease in respiratory flux, both in humans and in rodents. Here, we dissect the underlying mechanism of mitochondrial flux decline by integrated analysis of the molecular network. Mice were given a lifelong ad libitum low-fat or high-fat sucrose diet and were further divided into sedentary and running-wheel groups. At 6, 12, ...[more]