MiR-149 in Human Cancer: A Systemic Review.

ABSTRACT: MicroRNAs (miRNAs) are small noncoding RNAs that regulate post-transcriptional gene expression via binding to the 3'-untranslated region (3'-UTR) of targeted mRNAs. They are reported to play important roles in tumorigenesis and progression of various cancers. Among them, miR-149 was confirmed to be aberrantly regulated in various tumors. In this review, we provide a complex overview of miR-149, particularly summarize the critical roles of it in cancers and expect to lay the foundation for future works on this important microRNA.

SUBMITTER: He Y 

PROVIDER: S-EPMC5771345 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature