Ontology highlight
ABSTRACT:
SUBMITTER: Aguilar AL
PROVIDER: S-EPMC5771404 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Aguilar Aime Lopez AL Hou Xiaomeng X Wen Liuqing L Wang Peng G PG Wu Peng P
Chembiochem : a European journal of chemical biology 20171205 24
Modification of nuclear and cytoplasmic proteins by the addition or removal of O-GlcNAc dynamically impacts multiple biological processes. Here, we present the development of a chemoenzymatic histology method for the detection of O-GlcNAc in tissue specimens. We applied this method to screen murine organs, uncovering specific O-GlcNAc distribution patterns in different tissue structures. We then utilized our histology method for O-GlcNAc detection in human brain specimens from healthy donors and ...[more]