Ontology highlight
ABSTRACT:
SUBMITTER: McLellan CA
PROVIDER: S-EPMC5771894 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Nature chemical biology 20171211 2
The development of effective antifungal therapeutics remains a formidable challenge because of the close evolutionary relationship between humans and fungi. Mitochondrial function may present an exploitable vulnerability because of its differential utilization in fungi and its pivotal roles in fungal morphogenesis, virulence, and drug resistance already demonstrated by others. We now report mechanistic characterization of ML316, a thiohydantoin that kills drug-resistant Candida species at nanomo ...[more]