Ontology highlight
ABSTRACT:
SUBMITTER: Ferruz N
PROVIDER: S-EPMC5772633 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Ferruz Noelia N Doerr Stefan S Vanase-Frawley Michelle A MA Zou Yaozhong Y Chen Xiaomin X Marr Eric S ES Nelson Robin T RT Kormos Bethany L BL Wager Travis T TT Hou Xinjun X Villalobos Anabella A Sciabola Simone S De Fabritiis Gianni G
Scientific reports 20180117 1
The recent increase in the number of X-ray crystal structures of G-protein coupled receptors (GPCRs) has been enabling for structure-based drug design (SBDD) efforts. These structures have revealed that GPCRs are highly dynamic macromolecules whose function is dependent on their intrinsic flexibility. Unfortunately, the use of static structures to understand ligand binding can potentially be misleading, especially in systems with an inherently high degree of conformational flexibility. Here, we ...[more]