Ontology highlight
ABSTRACT:
SUBMITTER: Craig EA
PROVIDER: S-EPMC5773037 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Efficient movement of proteins across membranes is required for cell health. The translocation process is particularly challenging when the channel in the membrane through which proteins must pass is narrow-such as those in the membranes of the endoplasmic reticulum and mitochondria. Hsp70 molecular chaperones play roles on both sides of these membranes, ensuring efficient translocation of proteins synthesized on cytosolic ribosomes into the interior of these organelles. The "import motor" in th ...[more]