Ontology highlight
ABSTRACT:
SUBMITTER: Knyazev DG
PROVIDER: S-EPMC6028853 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Knyazev Denis G DG Kuttner Roland R Zimmermann Mirjam M Sobakinskaya Ekaterina E Pohl Peter P
The Journal of membrane biology 20180112 3
This review focusses on the energetics of protein translocation via the Sec translocation machinery. First we complement structural data about SecYEG's conformational rearrangements by insight obtained from functional assays. These include measurements of SecYEG permeability that allow assessment of channel gating by ligand binding and membrane voltage. Second we will discuss the power stroke and Brownian ratcheting models of substrate translocation and the role that the two models assign to the ...[more]