Ontology highlight
ABSTRACT:
SUBMITTER: Zhao J
PROVIDER: S-EPMC5773236 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Zhao Juanjuan J Cheng Liang L Wang Hongbo H Yu Haisheng H Tu Bo B Fu Qiang Q Li Guangming G Wang Qi Q Sun Yanling Y Zhang Xin X Liu Zhenwen Z Chen Weiwei W Zhang Liguo L Su Lishan L Zhang Zheng Z
PLoS pathogens 20180105 1
Innate lymphoid cells (ILCs) are severely depleted during chronic HIV-1 infection by unclear mechanisms. We report here that human ILC1s comprising of CD4+ and CD4- subpopulations were present in various human lymphoid organs but with different transcription programs and functions. Importantly, CD4+ ILC1s expressed HIV-1 co-receptors and were productively infected by HIV-1 in vitro and in vivo. Furthermore, chronic HIV-1 infection activated and depleted both CD4+ and CD4- ILC1s, and impaired the ...[more]