Ontology highlight
ABSTRACT:
SUBMITTER: Doitsh G
PROVIDER: S-EPMC3026834 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Doitsh Gilad G Cavrois Marielle M Lassen Kara G KG Zepeda Orlando O Yang Zhiyuan Z Santiago Mario L ML Hebbeler Andrew M AM Greene Warner C WC
Cell 20101101 5
The mechanism by which CD4 T cells are depleted in HIV-infected hosts remains poorly understood. In ex vivo cultures of human tonsil tissue, CD4 T cells undergo a pronounced cytopathic response following HIV infection. Strikingly, >95% of these dying cells are not productively infected but instead correspond to bystander cells. We now show that the death of these "bystander" cells involves abortive HIV infection. Inhibitors blocking HIV entry or early steps of reverse transcription prevent CD4 T ...[more]