Ontology highlight
ABSTRACT:
SUBMITTER: Evavold CL
PROVIDER: S-EPMC5773350 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Evavold Charles L CL Ruan Jianbin J Tan Yunhao Y Xia Shiyu S Wu Hao H Kagan Jonathan C JC
Immunity 20171128 1
The interleukin-1 (IL-1) family cytokines are cytosolic proteins that exhibit inflammatory activity upon release into the extracellular space. These factors are released following various cell death processes, with pyroptosis being a common mechanism. Recently, it was recognized that phagocytes can achieve a state of hyperactivation, which is defined by their ability to secrete IL-1 while retaining viability, yet it is unclear how IL-1 can be secreted from living cells. Herein, we report that th ...[more]