Ontology highlight
ABSTRACT:
SUBMITTER: Honda T
PROVIDER: S-EPMC5773541 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Honda Takuya T Morii Mariko M Nakayama Yuji Y Suzuki Ko K Yamaguchi Noritaka N Yamaguchi Naoto N
Scientific reports 20180118 1
v-Src is the first identified oncogene product and has a strong tyrosine kinase activity. Much of the literature indicates that v-Src expression induces anchorage-independent and infinite cell proliferation through continuous stimulation of growth signaling by v-Src activity. Although all of v-Src-expressing cells are supposed to form transformed colonies, low frequencies of v-Src-induced colony formation have been observed so far. Using cells that exhibit high expression efficiencies of inducib ...[more]