Ontology highlight
ABSTRACT:
SUBMITTER: Streit J
PROVIDER: S-EPMC5773578 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Streit Jonas J Kleinlogel Sonja S
Scientific reports 20180118 1
Voltage-gated ion channels (VGCs) are prime targets for the pharmaceutical industry, but drug profiling on VGCs is challenging, since drug interactions are confined to specific conformational channel states mediated by changes in transmembrane potential. Here we combined various optogenetic tools to develop dynamic, high-throughput drug profiling assays with defined light-step protocols to interrogate VGC states on a millisecond timescale. We show that such light-induced electrophysiology (LiEp) ...[more]