Ventricular voltage-gated ion channels: Detection, characteristics, mechanisms, and drug safety evaluation.

ABSTRACT: Cardiac voltage-gated ion channels (VGICs) play critical roles in mediating cardiac electrophysiological signals, such as action potentials, to maintain normal heart excitability and contraction. Inherited or acquired alterations in the structure, expression, or function of VGICs, as well as VGIC-related side effects of pharmaceutical drug delivery can result in abnormal cellular electrophysiological processes that induce life-threatening cardiac arrhythmias or even sudden cardiac death. Hence, to reduce possible heart-related risks, VGICs must be acknowledged as important targets in drug discovery and safety studies related to cardiac disease. In this review, we first summarize the development and application of electrophysiological techniques that are employed in cardiac VGIC studies alo

SUBMITTER: Chen L 

PROVIDER: S-EPMC8516344 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature