Ontology highlight
ABSTRACT:
SUBMITTER: Cottier F
PROVIDER: S-EPMC5773663 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Cottier Fabien F Srinivasan Kandhadayar Gopalan KG Yurieva Marina M Yurieva Marina M Liao Webber W Poidinger Michael M Zolezzi Francesca F Pavelka Norman N
NPJ biofilms and microbiomes 20180118
Sequencing-based microbiome profiling aims at detecting and quantifying individual members of a microbial community in a culture-independent manner. While amplicon-based sequencing (ABS) of bacterial or fungal ribosomal DNA is the most widely used technology due to its low cost, it suffers from PCR amplification biases that hinder accurate representation of microbial population structures. Shotgun metagenomics (SMG) conversely allows unbiased microbiome profiling but requires high sequencing dep ...[more]