Ontology highlight
ABSTRACT:
SUBMITTER: Barriga FM
PROVIDER: S-EPMC5774992 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Cell stem cell 20170309 6
Highly proliferative Lgr5+ stem cells maintain the intestinal epithelium and are thought to be largely homogeneous. Although quiescent intestinal stem cell (ISC) populations have been described, the identity and features of such a population remain controversial. Here we report unanticipated heterogeneity within the Lgr5+ ISC pool. We found that expression of the RNA-binding protein Mex3a labels a slowly cycling subpopulation of Lgr5+ ISCs that contribute to all intestinal lineages with distinct ...[more]