Ontology highlight
ABSTRACT:
SUBMITTER: Pereira B
PROVIDER: S-EPMC7132344 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Pereira Bruno B Amaral Ana L AL Dias Alexandre A Mendes Nuno N Muncan Vanesa V Silva Ana R AR Thibert Chantal C Radu Anca G AG David Leonor L Máximo Valdemar V van den Brink Gijs R GR Billaud Marc M Almeida Raquel R
EMBO reports 20200213 4
Intestinal stem cells (ISCs) fuel the lifelong self-renewal of the intestinal tract and are paramount for epithelial repair. In this context, the Wnt pathway component LGR5 is the most consensual ISC marker to date. Still, the effort to better understand ISC identity and regulation remains a challenge. We have generated a Mex3a knockout mouse model and show that this RNA-binding protein is crucial for the maintenance of the Lgr5<sup>+</sup> ISC pool, as its absence disrupts epithelial turnover d ...[more]