Ontology highlight
ABSTRACT:
SUBMITTER: Yamamura H
PROVIDER: S-EPMC5777270 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Yamamura Hisao H Nishimura Kaori K Hagihara Yumiko Y Suzuki Yoshiaki Y Imaizumi Yuji Y
The Journal of biological chemistry 20171129 3
Pinealocytes regulate circadian rhythm by synthesizing and secreting melatonin. These cells generate action potentials; however, the contribution of specific ion channels to melatonin secretion from pinealocytes remains unclear. In this study, the involvement and molecular identity of Ca<sup>2+</sup>-activated Cl<sup>-</sup> (Cl<sub>Ca</sub>) channels in the regulation of melatonin secretion were examined in rat pineal glands. Treatment with the Cl<sub>Ca</sub> channel blockers, niflumic acid or ...[more]