Ontology highlight
ABSTRACT:
SUBMITTER: Lee B
PROVIDER: S-EPMC6802608 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Lee Byeongjun B Hong Gyu-Sang GS Lee Sung Hoon SH Kim Hyungsup H Kim Ajung A Hwang Eun Mi EM Kim Jiyoon J Lee Min Goo MG Yang Jin-Young JY Kweon Mi-Na MN Tse Chung-Ming CM Mark Donowitz D Oh Uhtaek U
Experimental & molecular medicine 20190805 8
Calcium-activated chloride channels (CaCCs) mediate numerous physiological functions and are best known for the transport of electrolytes and water in epithelia. In the intestine, CaCC currents are considered necessary for the secretion of fluid to protect the intestinal epithelium. Although genetic ablation of ANO1/TMEM16A, a gene encoding a CaCC, reduces the carbachol-induced secretion of intestinal fluid, its mechanism of action is still unknown. Here, we confirm that ANO1 is essential for th ...[more]