Ontology highlight
ABSTRACT:
SUBMITTER: Topf U
PROVIDER: S-EPMC5778013 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Nature communications 20180122 1
The generation of reactive oxygen species (ROS) is inevitably linked to life. However, the precise role of ROS in signalling and specific targets is largely unknown. We perform a global proteomic analysis to delineate the yeast redoxome to a depth of more than 4,300 unique cysteine residues in over 2,200 proteins. Mapping of redox-active thiols in proteins exposed to exogenous or endogenous mitochondria-derived oxidative stress reveals ROS-sensitive sites in several components of the translation ...[more]