Dataset Information

Subclinical Cardiac Dysfunction and Brain Health in Midlife: CARDIA (Coronary Artery Risk Development in Young Adults) Brain Magnetic Resonance Imaging Substudy.

ABSTRACT:

Background

We investigated whether cardiac parameters in young adulthood are associated with indicators of brain health in midlife.

Methods and results

This study includes 648 participants from the CARDIA (Coronary Artery Risk Development in Young Adults) study (52% women, 38% black). We studied associations of cardiac parameters assessed by echocardiography (left ventricular ejection fraction, left atrial volume, and left ventricular mass) in young adulthood (mean age: 30 years) with brain measures obtained by magnetic resonance imaging (total brain, gray and white matter volume, white matter integrity, abnormal white matter) in midlife (mean age: 50 years). In 406 individuals with complete measurements, higher left atrial volume was associated with lower white matter fractional anisotropy, independent of traditional cardiovascular risk factors (?=-0.002; P <0.02). The association was strongest in black participants and in men.

Conclusions

Higher left atrial volume in early adulthood is associated with impairment of white matter integrity in midlife. Interventions to improve cardiac function in young adults may benefit brain health and should be targeted in particular at black men.

SUBMITTER: Cermakova P

PROVIDER: S-EPMC5779005 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Publications

Subclinical Cardiac Dysfunction and Brain Health in Midlife: CARDIA (Coronary Artery Risk Development in Young Adults) Brain Magnetic Resonance Imaging Substudy.

Cermakova Pavla P Muller Majon M Armstrong Anderson C AC Religa Dorota D Bryan R Nick RN Lima João A C JAC Launer Lenore J LJ

Journal of the American Heart Association 20171215 12

<h4>Background</h4>We investigated whether cardiac parameters in young adulthood are associated with indicators of brain health in midlife.<h4>Methods and results</h4>This study includes 648 participants from the CARDIA (Coronary Artery Risk Development in Young Adults) study (52% women, 38% black). We studied associations of cardiac parameters assessed by echocardiography (left ventricular ejection fraction, left atrial volume, and left ventricular mass) in young adulthood (mean age: 30 years) ...[more]

PMID: 29246962

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Dataset Information

Subclinical Cardiac Dysfunction and Brain Health in Midlife: CARDIA (Coronary Artery Risk Development in Young Adults) Brain Magnetic Resonance Imaging Substudy.

Background

Methods and results

Conclusions

Publications

Subclinical Cardiac Dysfunction and Brain Health in Midlife: CARDIA (Coronary Artery Risk Development in Young Adults) Brain Magnetic Resonance Imaging Substudy.

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