Ontology highlight
ABSTRACT:
SUBMITTER: Hassanpour N
PROVIDER: S-EPMC5779715 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Metabolic engineering communications 20170301
Directed evolution of enzymes consists of an iterative process of creating mutant libraries and choosing desired phenotypes through screening or selection until the enzymatic activity reaches a desired goal. The biggest challenge in directed enzyme evolution is identifying high-throughput screens or selections to isolate the variant(s) with the desired property. We present in this paper a computational metabolic engineering framework, Selection Finder (SelFi), to construct a selection pathway fr ...[more]