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A tethering directing group strategy for ruthenium-catalyzed intramolecular alkene hydroarylation.

ABSTRACT: We report a new catalyst design for N-heterocycle synthesis that utilizes an alkene-tethered amide moiety as a directing group for aromatic C-H activation. This tethering directing group strategy is demonstrated in a ruthenium-catalyzed intramolecular alkene hydroarylation with N-aryl acrylamides to form oxindole products.

SUBMITTER: Kilaru P 

PROVIDER: S-EPMC5780245 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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A tethering directing group strategy for ruthenium-catalyzed intramolecular alkene hydroarylation.

Kilaru Praveen P   Acharya Sunil P SP   Zhao Pinjing P  

Chemical communications (Cambridge, England) 20180101 8

We report a new catalyst design for N-heterocycle synthesis that utilizes an alkene-tethered amide moiety as a directing group for aromatic C-H activation. This tethering directing group strategy is demonstrated in a ruthenium-catalyzed intramolecular alkene hydroarylation with N-aryl acrylamides to form oxindole products. ...[more]

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