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Incidence and mortality of fractures by frailty level over 80 years of age: cohort study using UK electronic health records.

ABSTRACT: OBJECTIVE:This study aimed to estimate the association of frailty with incidence and mortality of fractures at different sites in people aged over 80 years. DESIGN:Cohort study. SETTING:UK family practices from 2001 to 2014. PARTICIPANTS:265?195 registered participants aged 80 years and older. MEASUREMENTS:Frailty status classified into 'fit', 'mild', 'moderate' and 'severe' frailty. Fractures, classified into non-fragility and fragility, including fractures of femur, pelvis, shoulder and upper arm, and forearm/wrist. Incidence of fracture, and mortality within 90 days and 1?year, were estimated. RESULTS:There were 28?643 fractures including: non-fragility fractures, 9101; femur, 12 501; pelvis, 2172; shoulder and upper arm, 4965; and forearm/wrist, 6315. The incidence of each fracture type was higher in women and increased with frailty category (femur, severe frailty compared with 'fit', incidence rate ratio (IRR) 2.4, 95% CI 2.3 to 2.6). Fractures of the femur (95-99 years compared with 80-84 years, IRR 2.7, 95% CI 2.6 to 2.9) and pelvis (IRR 2.9, 95% CI 2.5 to 3.3) were strongly associated with age but non-fragility and forearm fractures were not. Mortality within 90 days was greatest for femur fracture (adjusted HR, compared with forearm fracture 4.3, 95% CI 3.7 to 5.1). Mortality was higher in men and increased with age (HR 5.3, 95% CI 4.3 to 6.5 in those over 100 years compared with 80-84 years) but was less strongly associated with frailty category. Similar associations with fractures were seen at 1-year mortality. CONCLUSIONS:The incidence of fractures at all sites was higher in women and strongly associated with advancing frailty status, while the risk of mortality after a fracture was greater in men and was associated with age rather than frailty category.

SUBMITTER: Ravindrarajah R

PROVIDER: S-EPMC5781050 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Incidence and mortality of fractures by frailty level over 80 years of age: cohort study using UK electronic health records.

Ravindrarajah Rathi R Hazra Nisha C NC Charlton Judith J Jackson Stephen H D SHD Dregan Alex A Gulliford Martin C MC

BMJ open 20180121 1

<h4>Objective</h4>This study aimed to estimate the association of frailty with incidence and mortality of fractures at different sites in people aged over 80 years.<h4>Design</h4>Cohort study.<h4>Setting</h4>UK family practices from 2001 to 2014.<h4>Participants</h4>265 195 registered participants aged 80 years and older.<h4>Measurements</h4>Frailty status classified into 'fit', 'mild', 'moderate' and 'severe' frailty. Fractures, classified into non-fragility and fragility, including fractures o ...[more]

PMID: 29358434

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Project description:BACKGROUND:Clinical trials show benefit from lowering systolic blood pressure (SBP) in people ?80 years of age, but nonrandomized epidemiological studies suggest lower SBP may be associated with higher mortality. This study aimed to evaluate associations of SBP with all-cause mortality by frailty category >80 years of age and to evaluate SBP trajectories before death. METHODS:A population-based cohort study was conducted using electronic health records of 144?403 participants ?80 years of age registered with family practices in the United Kingdom from 2001 to 2014. Participants were followed for ?5 years. Clinical records of SBP were analyzed. Frailty status was classified using the e-Frailty Index into the categories of fit, mild, moderate, and severe. All-cause mortality was evaluated by frailty status and mean SBP in Cox proportional-hazards models. SBP trajectories were evaluated using person months as observations, with mean SBP and antihypertensive treatment status estimated for each person month. Fractional polynomial models were used to estimate SBP trajectories over 5 years before death. RESULTS:During follow-up, 51?808 deaths occurred. Mortality rates increased with frailty level and were greatest at SBP <110 mm?Hg. In fit women, mortality was 7.7 per 100 person years at SBP 120 to 139 mm?Hg, 15.2 at SBP 110 to 119 mm?Hg, and 22.7 at SBP <110 mm?Hg. For women with severe frailty, rates were 16.8, 25.2, and 39.6, respectively. SBP trajectories showed an accelerated decline in the last 2 years of life. The relative odds of SBP <120 mm?Hg were higher in the last 3 months of life than 5 years previously in both treated (odds ratio, 6.06; 95% confidence interval, 5.40-6.81) and untreated (odds ratio, 6.31; 95% confidence interval, 5.30-7.52) patients. There was no evidence of intensification of antihypertensive therapy in the final 2 years of life. CONCLUSIONS:A terminal decline of SBP in the final 2 years of life suggests that nonrandomized epidemiological associations of low SBP with higher mortality may be accounted for by reverse causation if participants with lower blood pressure values are closer, on average, to the end of life.

Project description:BackgroundThe posterior malleolus component of the trimalleolar ankle fracture has posed a controversial topic for diagnostic imaging and surgical management. Preoperative computed tomography (CT) scans are used to better appreciate fracture morphology and may affect management techniques. No prior study has investigated the trend in preoperative CT scan use and the rates of posterior and syndesmotic fixation for trimalleolar injuries.MethodsThis retrospective cohort study evaluated the use of preoperative CT scans and the rates of posterior and syndesmotic fixation for trimalleolar ankle fractures over a 10-year period at an adult level 1 trauma center. Patients surgically managed for ankle fractures with OTA/AO classifications of 44B3, 44C3.3, 44C1.3, 44C2.3, and 44A3 were identified and included using Current Procedural Terminology codes and a prospectively collected fracture registry. Demographic information, comorbidities, fixation methods, and use of preoperative CT scan were recorded. Comparative analyses were performed to assess for yearly differences in demographic characteristics along with changes in trends of preoperative CT scans and posterior and syndesmotic fixation.ResultsA total of 1191 patients were included in the analyses. OTA/AO 44B3.2 fractures were the most common injuries (yearly range of 59.4%-80.1%). The rate of posterior fixation did not significantly increase during the study interval (1.4% growth per year [95% CI -0.27, 3.07]). However, the rate of preoperative CT scan use significantly increased by 2.76% (95% CI 1.99, 3.52) per year and the rate of syndesmotic fixation increased by 2.58% (95% CI 1.17, 3.99) per year. Fixation methods for both the syndesmosis and posterior malleolus changed during the study timeline.ConclusionDespite a relatively stable rate of posterior fixation, the frequency of preoperative CT scans and use of syndesmotic fixation increased significantly over a 10-year study period.Level of evidenceLevel IV, descriptive pilot study.

Dataset Information

Incidence and mortality of fractures by frailty level over 80 years of age: cohort study using UK electronic health records.

Publications

Incidence and mortality of fractures by frailty level over 80 years of age: cohort study using UK electronic health records.

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