Ontology highlight
ABSTRACT:
SUBMITTER: Deng L
PROVIDER: S-EPMC5783933 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Deng Lei L Mohan Teena T Chang Timothy Z TZ Gonzalez Gilbert X GX Wang Ye Y Kwon Young-Man YM Kang Sang-Moo SM Compans Richard W RW Champion Julie A JA Wang Bao-Zhong BZ
Nature communications 20180124 1
Current influenza vaccines provide limited protection against circulating influenza A viruses. A universal influenza vaccine will eliminate the intrinsic limitations of the seasonal flu vaccines. Here we report methodology to generate double-layered protein nanoparticles as a universal influenza vaccine. Layered nanoparticles are fabricated by desolvating tetrameric M2e into protein nanoparticle cores and coating these cores by crosslinking headless HAs. Representative headless HAs of two HA phy ...[more]