Micro(glial)-managing executive function: white matter inflammation drives catatonia.
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ABSTRACT:
SUBMITTER: Pease-Raissi SE
PROVIDER: S-EPMC5785255 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Publications
Micro(glial)-managing executive function: white matter inflammation drives catatonia.
Pease-Raissi Sarah E SE Chan Jonah R JR
The Journal of clinical investigation 20171218 2
White matter abnormalities are prevalent in neuropsychiatric disorders such as schizophrenia, but it is unclear whether these abnormalities represent a cause or consequence of these disorders. Reduced levels of the myelin protein 2'-3'-cyclic nucleotide 3'-phosphodiesterase (CNP) are associated with the schizophrenic symptom catatonia in both humans and mouse models. In this issue of the JCI, Janova et al. show that reduced CNP levels correlate with catatonia and white matter inflammation in hum ...[more]
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